Along with its needed effects, naproxen/sumatriptan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Treximet® (sumatriptan and naproxen sodium) is a selective 5-HT1B/1D receptor agonist and antiinflammatory indicated for the acute treatment of migraine, with or without aura, in adults and pediatric patients 12 years of age and older who have a clear migraine diagnosis. Managing Severe Migraine Side Effects Medically reviewed by George T. Krucik, MD, MBA on March 18, 2015 — Written by Lindsey Konkel Just like every person is different, every migraine is different. Side Effects to watch for. Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue This may lead to more methotrexate or aminoglycoside-related side effects. Individuals taking anticoagulants , for example, warfarin , ( Coumadin ), should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding. Does Naproxen work for Migraine? Read reviews and side effects. This is available both OTC as well as prescription, and can be taken orally to treat the pain associated with migraines. Side effects from naproxen are more frequent if you need to take this medication over a long period of time. Digestive system complaints are the most frequent side effects of naproxen. Take naproxen tablets with or just after a meal or snack. Take the lowest dose of naproxen for the shortest time to control your symptoms. The most common side effects of naproxen are confusion, headache, ringing in the ears, changes in vision, tiredness, drowsiness, dizziness and rashes. Naproxen can pass into breast milk and may cause side effects in the nursing baby. You should not breast-feed while using this medicine. You should not breast-feed while using this medicine. Naproxen is not approved for use by anyone younger than 2 years old. Since both ibuprofen and naproxen are NSAIDs, they have similar side effects and adverse effects. Ibuprofen and naproxen may increase the risk of blood clots, heart attack, and stroke. Common side effects of both drugs include heartburn, constipation, nausea, diarrhea, abdominal pain, dizziness, headaches, drowsiness, and tinnitus (ringing in the ears). Other serious side effects include edema.